Journal article
Taz-camta1 and yap-tfe3 alter the taz/yap transcriptome by recruiting the atac histone acetyltransferase complex
N Merritt, K Garcia, D Rajendran, ZY Lin, X Zhang, KM Mitchell, N Borcherding, C Fullenkamp, MS Chimenti, AC Gingras, KF Harvey, MR Tanas
Elife | eLIFE SCIENCES PUBL LTD | Published : 2021
DOI: 10.7554/ELIFE.62857
Abstract
Epithelioid hemangioendothelioma (EHE) is a vascular sarcoma that metastasizes early in its clinical course and lacks an effective medical therapy. The TAZ-CAMTA1 and YAP-TFE3 fusion proteins are chimeric transcription factors and initiating oncogenic drivers of EHE. A combined proteomic/genetic screen in human cell lines identified YEATS2 and ZZZ3, components of the Ada2acontaining histone acetyltransferase (ATAC) complex, as key interactors of both fusion proteins despite the dissimilarity of the C terminal fusion partners CAMTA1 and TFE3. Integrative next generation sequencing approaches in human and murine cell lines showed that the fusion proteins drive a unique transcriptome by simulta..
View full abstractGrants
Awarded by Genome Canada
Funding Acknowledgements
Veterans Health Administration Merit Review Program 1 I01 BX003644-01 Munir R Tanas National Institutes of Health R01 CA237031-01A1 Munir R Tanas National Health and Medical Research Council APP1078220 Kieran F Harvey Canadian Institutes of Health Research FDN 144301 Anne-Claude Gingras University of Iowa N/A Munir R Tanas NCI P30 CA086862 Munir R Tanas National Health and Medical Research Council APP1078220 Kieran F Harvey Canadian Institutes of Health Research FDN 144301 Anne-Claude Gingras Terry Fox Research Institute N/A Anne-Claude Gingras Lunenfeld-Tanenbaum Research Institute N/A Anne-Claude Gingras Canada Foundation for Innovation N/A Anne-Claude Gingras Ontario Genomics OGI-139 Anne-Claude Gingras National Institutes of Health R01 CA237031-01A1S1 Munir R Tanas The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.